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Tacrolimus toxicity was noted with concomitant use of the prescription CBD merchandise (Epidiolex). CBD and its active metabolite show exercise at various degrees on numerous P450 isoforms, including CYP3A4 and 2C19, along with at P-glycoprotein and glucuronidation pathways.Cannabidiol may be used for selected forms of epilepsy. Dronabinol may be u